Callerio Foundation

Microsphere

The core-facility Microsphere originates from the studies on the fish vaccination of fish-breeding factories.
Those studies prompted Callerio Foundation researchers to undertake studies and to get expertieses on how to protect active principles to be administered orally and to give systemic pharmacological actions.
Microsphere is now a well organized facility equipped to prepare oral delivery sistems based on natural sugars useful for the incapsulation of active principles of different origin.

With the Project “Microsphere” the Callerio Foundation aims to investigate the potential uses of Lysozyme, the protein discovered by the Nobel Prize Alexander Fleming, that prompted the founders Carlo Callerio and Dirce Babudieri to affirm the Società Prodotti Antibiotici of Milan and to build up the Callerio Foundation at Trieste.

In particular, the Project “Microsphere” is focused on the evaluation of the potential commercial falls deriving from the exploitation of the intellectual property of the patents “Microcapsule a doppio strato di polisaccaridi utilizzabili come veicoli per la somministrazione orale di sostanze biologicamente attive” registered by the Fondazione Callerio on 2003 (MI2003A001617) and subsequently extended with the international PCT WO 2005/013941

This work follows the pioneering study carried out in the years 1998-1999 and financed with the Fondo Trieste in the frame of the project VALSIPAV (Validazione del Lisozima per la Stimolazione dell’Immunità dei Pesci di Allevamento in Trattamento Vaccinogeno).

The Project “Microsphere” started officially with the participation of young researchers of Callerio Foundation to the “Start Cup 2005” competition organized by the University of Trieste and finalized to the evaluations of the innovative projects present in the Friuli Venezia Giulia Region . The project, presented with the title “Microsphere – sistemi microincapsulati per la somministrazione orale di principi biologicamente attivi” was ranked among the first ten best projects presented at that competition.

Active Collaborations
  • Department of Pharmaceutical Sciences (University of Trieste), prof. D. Voinovich: studies of   formulations of microspheres with different properties of uptake and release.
  • Zooprophilactic Institute of Abruzzo and Molise: project to validate microspheres as carriers of vaccines consisting of inactivated bacteria for the prophylactic treatment of trouts and sea basses.
  • AREA Science Park of Trieste, project SISTER: studies for patenting and validation tests.
  • AREA Science Park of Trieste, project Innovation Factory: co-operation for the spin-off.