Callerio Foundation
NEWS - Olomouc - Czech Republic, March 21th - 23th, 2013

COST Action CM1105 Working Group # 4 meeting

Metallodrugs II: Design and mechanism of action


The COST Action CM1105 Working Group # 4 meeting “Metallodrugs II: Design and mechanism of action” was organized by the Department of Biophysics, Faculty of Science, Palacky University, Olomouc, and by the Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno.

The COST Action CM1105, and the Operational Program Education for Competitiveness-European Social Fund (CZ 1.07/2.3.00/20.0057) of the Ministry of Education, Youth and Sports of the Czech Republic supported the organization of the meeting, held in Olomouc from March 21st – 23rd.
Researchers from Callerio Foundation, involved in WG1 of the same COST Action, had the opportunity to attend the meeting, thanks to the kind hospitality of the meeting organizers prof. Brabec and dr. Kasparkova, and of the WG4 leader prof. Bednarski.
About forty researchers, coming from 8 different European countries, attended the meeting, bringing their latest results on the interactions of metallo-drugs on the cellular level.
Many oral presentations dealt with cisplatin, and other Pt compounds, with interactions of metal complexes with proteins involved in their transport and accumulation, as well as with cellular constituents and pathways responsible of the resistance mechanisms against their cytotoxicity raised in cancer cells.
Room was devoted to compounds designed to overcome the hurdle of cisplatin resistance, looking for unusual DNA interactions, for cellular targets different from DNA (peroxidase inhibitors), and for novel approaches, such as those exploiting the Cationic Antimicrobial Peptides (CATs), or the photoactivation of old and new synthesized compounds. Platinum is not the only metal on which chemists are working: many compounds based on different metals, among them Ruthenium, Iridium, Copper, Silver, and Osmium, were presented, and their biological activity reported.

The participation of chemists, biologists, biochemists, and pharmacologists contributed to the high level of inter-disciplinarity of the meeting, leading to stimulating discussions ranging among different and complementary topics.
At the same time, this event stimulated the activation of new interactions and collaborations. Another “hit” of the meeting was the active participation of many Early Stage Researchers (ESRs): in fact approximately 50% of attendees were PhD students, or Post-doc researchers, who actively contributed to the success of the meeting describing the results of their studies.
This aspect highlights the formation role of the COST Action initiatives once again, and their importance in the maintaining of the primary position that European research on metal-based compounds holds worldwide.


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