Callerio Foundation
NEWS - Trieste - Italy, April 11th - 12th, 2014

COST Action CM1105

WG1 MEETING “Potentialities of Metal-based compounds targeting proteins”


April 11th and 12th the meeting of the WG1 group “Protein Targets” of the COST Action CM1105 took place in Trieste.

The scientific part was organized in three sessions, of which the main objectives were to focus on “Up-to-date on the application of metal-based compounds”, on “Mechanistic insights”, and on “Early Stage Researchers studies”.

The participants have reported on metal-based compounds useful for subcellular imaging (Re tricarbonyl complexes), or as theranostic agents for PDT and imaging depending on the metal centre (respectively Re and 99mTc) conjugated to porphyrins, also trying to categorize their chemical features in order to allow a more systematic design approach.

In addition, the activity of metal-compounds combined to electrochemotherapy was explored and presented.
Among the potential targets of metal-based compounds, integrins maintain lively interest.
Mechanistic studies on their involvement in adhesion and metastasis processes controlled by Ruthenium compounds are under investigation by different groups of WG1 network, and were presented by young participants. Other “Protein Targets” attracting the interest of researchers are transporters and enzymes. Many metal-based compounds are designed and synthesized de novo to specifically act as enzyme inhibitors. Also compounds already known to have anti-cancer properties, such as RDCs, are now investigated for their ability to modulate redox enzymes. Redox metabolism of the tumour cells emerged as an intriguing topic, worth to be explored more in depth since it seems implicated also in the regulation of integrins during the adhesion processes. Compounds such as NAMI-A that is “an old at the job” still raises interest in the search of its mechanism of action in new models or with new techniques. Regarding the chemical features of the metal-based compounds, researches have directed the gaze to a variety of transition (Ru, Re, Os, Cu…) and also non transition metals (Si).

The meeting was carried out with the precise scope to allow active contributions of all the participants, reserving large space for scientific comments.
Lively discussions have characterized the meeting due to the multidisciplinary expertise of the attending researchers of the WG1, but also thanks to the presence of members coming from other WGs of the COST Action CM1105, in particular WG3, WG4 and WG5.
The special attention devoted to Early Stage Researchers in special scheduled session, to give them the opportunity to engage and to practice scientific presentations in a familiar and cool atmosphere, was fully reciprocated: all of them participated actively and with enthusiasm taking advantage of all the opportunities offered by the meeting.


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